Chemical Constituents and Biological Significance of the Genus Ilex (Aquifoliaceae)

Title:Chemical Constituents and Biological Significance of the Genus Ilex (Aquifoliaceae)

Volume: 2 Issue: 3

Author(s): Sudhir K. Kothiyal, Satish C. Sati, Mohan S. M. Rawat, Manisha D. Sati, Deepak K. Semwal, Ruchi B. Semwal, Amita Sharma, Bipin Rawat and Ashok Kumar

Affiliation:

Keywords: Ilex; aquifoliaceae, triterpenoids, saponins, cytotoxic, antioxidant, CNS stimulants, mate tree, flavonoids, bioactive constituents.

Abstract: The genus Ilex (Aquifoliaceae) was reviewed for its chemical constituents and pharmacological significance including traditional uses. The structure-activity relationship for various compounds was illustrated to understand the mechanism of a particular activity. The genus has been known for its numerous biological activities like antioxidant, antimicrobial, cytotoxic, anti-platelet aggregation, anti-inflammatory etc. Most of the plants of this genus are rich sources of triterpenoids and saponins. Besides, these plants also contain flavonoids, alkaloids, anthocyanins and other phenolics in minute quantity. The bioactive constituents or plants extracts themselves, in the form of herbal drugs from this genus, have been validated for the treatment of various diseases and these would be used as a new formulation for the novel drugs discovery in pharmaceutical industries.

Cite this article as:

K. Kothiyal Sudhir, C. Sati Satish, S. M. Rawat Mohan, D. Sati Manisha, K. Semwal Deepak, B. Semwal Ruchi, Sharma Amita, Rawat Bipin and Kumar Ashok, Chemical Constituents and Biological Significance of the Genus Ilex (Aquifoliaceae), The Natural Products Journal 2012; 2 (3) . https://dx.doi.org/10.2174/2210315511202030212