Abstract
Turmeric contains three important analogs, curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), collectively called as curcuminoids. Curcumin, the most abundant of these curcuminoids is reported to have antioxidant, anti-inflammatory, neuroprotective, antimicrobial, nematocidal, antimutagenic, anticarcinogenic, antiretroviral and chemopreventive activities. Curcumin (a symmetric β diketone) analogs 3a-e were synthesized from β- diketones and aromatic aldehydes using solid phase microwave irradiation method in presence of boric acid in diethanolamine, acetic acid (1:1) with reduced reaction time and enhanced %yield. Various clays like Alumina (neutral), Silica gel and Montmorillonite K10 were used as solid phase catalysts where alumina was found to be efficient in the synthesis of curcumin analogs
Keywords: Aldol condensation, boron-assisted, curcumin analogs, microwave irradiation, regioselective, solid-phase, anticarcinogenic, antimutagenic, chemopreventive, antiretroviral
Letters in Organic Chemistry
Title:Solid-Phase Microwave Assisted Synthesis of Curcumin Analogs
Volume: 9 Issue: 6
Author(s): Dinesh Pore, Ramesh Alli, Achanta S.C. Prabhakar, Rajashekar R. Alavala, Umasankar Kulandaivelu and Shireesha Boyapati
Affiliation:
Keywords: Aldol condensation, boron-assisted, curcumin analogs, microwave irradiation, regioselective, solid-phase, anticarcinogenic, antimutagenic, chemopreventive, antiretroviral
Abstract: Turmeric contains three important analogs, curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), collectively called as curcuminoids. Curcumin, the most abundant of these curcuminoids is reported to have antioxidant, anti-inflammatory, neuroprotective, antimicrobial, nematocidal, antimutagenic, anticarcinogenic, antiretroviral and chemopreventive activities. Curcumin (a symmetric β diketone) analogs 3a-e were synthesized from β- diketones and aromatic aldehydes using solid phase microwave irradiation method in presence of boric acid in diethanolamine, acetic acid (1:1) with reduced reaction time and enhanced %yield. Various clays like Alumina (neutral), Silica gel and Montmorillonite K10 were used as solid phase catalysts where alumina was found to be efficient in the synthesis of curcumin analogs
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Cite this article as:
Pore Dinesh, Alli Ramesh, S.C. Prabhakar Achanta, R. Alavala Rajashekar, Kulandaivelu Umasankar and Boyapati Shireesha, Solid-Phase Microwave Assisted Synthesis of Curcumin Analogs, Letters in Organic Chemistry 2012; 9 (6) . https://dx.doi.org/10.2174/157017812801322417
DOI https://dx.doi.org/10.2174/157017812801322417 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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