Abstract
Irritable bowel syndrome is the most common functional gastrointestinal disorder characterized by chronic abdominal pain or discomfort in association with a change in bowel habit. 5-HT receptor modulators have been developed as IBS therapeutic agents and proved to be effective in the treatment of the disease. In this letter, 12 berberine derivatives were designed and synthesized as 5-HT receptor modulators. Preliminary biological tests suggested that the new compounds exhibited promising activity for IBS therapy.
Keywords: Irritable bowel syndrome (IBS), Berberine Derivatives, gastrointestinal (GI) disorder, intestinal flora, plasma 5-HT, CMC-Na solution, isoquinoline alkaloid, tetrahydroberineper
Letters in Drug Design & Discovery
Title:Synthesis and Biological Evaluation of Berberine Derivatives as IBS Modulator
Volume: 9 Issue: 5
Author(s): Xin Deng, Xinxin Zhao, Jing Han, Jingjie Wang, Wenlong Huang, Hai Qian, Liang Ge
Affiliation:
Keywords: Irritable bowel syndrome (IBS), Berberine Derivatives, gastrointestinal (GI) disorder, intestinal flora, plasma 5-HT, CMC-Na solution, isoquinoline alkaloid, tetrahydroberineper
Abstract: Irritable bowel syndrome is the most common functional gastrointestinal disorder characterized by chronic abdominal pain or discomfort in association with a change in bowel habit. 5-HT receptor modulators have been developed as IBS therapeutic agents and proved to be effective in the treatment of the disease. In this letter, 12 berberine derivatives were designed and synthesized as 5-HT receptor modulators. Preliminary biological tests suggested that the new compounds exhibited promising activity for IBS therapy.
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Cite this article as:
Xin Deng, Xinxin Zhao, Jing Han, Jingjie Wang, Wenlong Huang, Hai Qian, Liang Ge , Synthesis and Biological Evaluation of Berberine Derivatives as IBS Modulator, Letters in Drug Design & Discovery 2012; 9 (5) . https://dx.doi.org/10.2174/157018012800389386
DOI https://dx.doi.org/10.2174/157018012800389386 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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