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Current Vascular Pharmacology

Editor-in-Chief

ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Cell-Based Therapy to Promote Angiogenesis in the Brain Following Ischemic Damage

Author(s): Masahiro Uemura, Yukiko Kasahara, Kazuyuki Nagatsuka and Akihiko Taguchi

Volume 10, Issue 3, 2012

Page: [285 - 288] Pages: 4

DOI: 10.2174/157016112799959369

Price: $65

Abstract

Cell-based therapies are a novel approach for regeneration of microvasculature. We have shown that administration of CD34-positive cells, the rich cell fraction of endothelial progenitor cells, after stroke induces angiogenesis that results in enhanced endogenous neurogenesis and functional recovery in a murine model. Moreover, injury-induced neurogenesis occurs in the human brain following a stroke during the acute to sub-acute period. Based on these observations, clinical trials of cell therapies that aim to regenerate micro-circulation in the brain following a stroke are ongoing worldwide. This review summarizes the current basic research findings about the link between angiogenesis and neurogenesis in the post-stroke brain and introduces the ongoing clinical trials of cell-based therapies for patients that have suffered a stroke.

Keywords: Angiogenesis, neurogenesis, stroke, neural stem cells, CD34-positive cells


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