Abstract
Immune responses against oxidized forms of LDL play a critical role in activation and regulation of the inflammatory process that characterizes all stages of atherosclerosis. In humans oxidized LDL is targeted by both IgM and IgG autoantibodies. Immunization of hypercholesterolemic animals with oxidized LDL has been shown to inhibit atherosclerosis demonstrating that at least some of these immune responses have a protective effect. The identification of the structures in oxidized LDL that are responsible for activation of immunity has made it possible to develop novel therapeutic approaches for treatment of atherosclerosis based on active (vaccines) and passive (antibodies) immunization. Studies performed in atherosclerosis-prone mice demonstrate that both peptide-based vaccines and recombinant IgG targeting epitopes in oxidized LDL significantly reduce atherosclerosis. There is also evidence antibodies against oxidized LDL could also be used for imaging atherosclerosis.
Keywords: Atherosclerosis, low density lipoprotein, antibodies, immunity, vaccine, inflammation, oxidation
Current Pharmaceutical Design
Title: Oxidized LDL Antibodies in Treatment and Risk Assessment of Atherosclerosis and Associated Cardiovascular Disease
Volume: 13 Issue: 10
Author(s): Jan Nilsson, Gunilla Nordin Fredrikson, Alexandru Schiopu, Prediman K. Shah, Bo Jansson and Roland Carlsson
Affiliation:
Keywords: Atherosclerosis, low density lipoprotein, antibodies, immunity, vaccine, inflammation, oxidation
Abstract: Immune responses against oxidized forms of LDL play a critical role in activation and regulation of the inflammatory process that characterizes all stages of atherosclerosis. In humans oxidized LDL is targeted by both IgM and IgG autoantibodies. Immunization of hypercholesterolemic animals with oxidized LDL has been shown to inhibit atherosclerosis demonstrating that at least some of these immune responses have a protective effect. The identification of the structures in oxidized LDL that are responsible for activation of immunity has made it possible to develop novel therapeutic approaches for treatment of atherosclerosis based on active (vaccines) and passive (antibodies) immunization. Studies performed in atherosclerosis-prone mice demonstrate that both peptide-based vaccines and recombinant IgG targeting epitopes in oxidized LDL significantly reduce atherosclerosis. There is also evidence antibodies against oxidized LDL could also be used for imaging atherosclerosis.
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Cite this article as:
Nilsson Jan, Nordin Fredrikson Gunilla, Schiopu Alexandru, Shah K. Prediman, Jansson Bo and Carlsson Roland, Oxidized LDL Antibodies in Treatment and Risk Assessment of Atherosclerosis and Associated Cardiovascular Disease, Current Pharmaceutical Design 2007; 13 (10) . https://dx.doi.org/10.2174/138161207780487557
DOI https://dx.doi.org/10.2174/138161207780487557 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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