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Current Radiopharmaceuticals

Editor-in-Chief

ISSN (Print): 1874-4710
ISSN (Online): 1874-4729

Magnetic Resonance Contrast Media Sensing In Vivo Molecular Imaging Agents: An Overview

Author(s): Massoud Amanlou, Seyed Davar Siadat, Dariush Norouzian, Seyed Esmaeil Sadat Ebrahimi, Mohammad Reza Aghasadeghi, Masoud Ghorbani, Mohammad Shafiee Alavidjeh, Davoud Nouri Inanlou, Ali Jabbari Arabzadeh and Mehdi Shafiee Ardestani

Volume 4, Issue 1, 2011

Page: [31 - 43] Pages: 13

DOI: 10.2174/1874471011104010031

Price: $65

Abstract

Metabolic imaging is commonly performed by nuclear medicine facilities such as PET or SPECT, etc. The production and biomedical applications of bio-molecular sensing in vivo MRI metabolic contrast agents has recently become of great universal research interest, which follows its great success as a potential cost effective, less radioactive, nuclear medicine alternative. Temperature, redox potential, enzyme activity, free radial/metal ion responsive and/or pH sensitive molecular metabolic MR contrast agents are among the famous instances exemplified, which basically promote MR image contrast enhancement ability to distinguish molecular metabolic/gene expression features. Overall, these MRI contrast agents provide a framework to achieve a greater degree of accuracy from MRI as a low cost, more available facility, non radioactive radiation producing and highly sensitive biomedical tool to propound as a new suggesting opponent for PET nuclear medicine imaging. In the present review, the design, development, examination and future of the above agents will be discussed in detail.

Keywords: Bio-molecular sensing in vivo MRI metabolic contrast agents, PET, SITE-SPECIFIC MOLECULAR CONTRAST AGENT DELIVERY, LIPOSOME, PHOSPHOLIPIDS, THE LIPOSOME-MOLECULAR CONTRAST AGENT, Targeting Ligands, ANTIBODY, Polyclonals vs Monoclonals, MOLECULAR CONTRAST AGENT-MONOCLONAL ANTIBODY CONJUGATES FOR MOLECULAR TARGETING


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