Effects of Plant Extracts on HIV-1 Protease

Title: Effects of Plant Extracts on HIV-1 Protease

Volume: 8 Issue: 7

Author(s): Jaime Ribeiro Filho, Heloina de Sousa Falcao, Leonia Maria Batista, Jose Maria Barbosa Filho and Marcia Regina Piuvezam

Affiliation:

Keywords: Review, natural products, plants, AIDS, HIV-1 Protease, Anti-HIV drugs, Plant Extracts, Acquired immunodeficiency syndrome, human immunodeficiency virus, anti-HIV drug therapy, CCR5, CXCR4, CD4 receptors, aspartyl-protease family, non-infectious virions, AIDS-chemotherapy, allergy, malaria, osteoporosis, hyperglycemia, Andrographis paniculata, Baphicacanthus cusia, Actinidia arguta, Alisma plantago-aquatica, Crinum macowani Baker, Rhus acuminata DC, Rhus javanica L, Magnolia genus, M. fargesii, M. obovata, M. oficinalis, Terminalia species, T. belerica, T. chebula, Geum japonicum, Punica granatum, Rhus javanica, T. arjuna, Woodwardia orientalis, W. unigemmata

Abstract: Acquired immunodeficiency syndrome (AIDS) is one of the most important public health problems, affecting many people every day. This syndrome is caused by the human immunodeficiency virus (HIV) and the HIV-1 protease plays an essential role by promoting virus maturation and thus infecting new cells. The HIV-1 protease is one of the main targets for anti-HIV drug therapy. The present work is a literature survey of plant extracts whose activity has been studied on HIV-1 protease. Here we list 275 species of medicinal plants, distributed in 99 families, with their place of origin, part used, type of extract, concentration and activity. We aim with this work to provide data that could be used in the research and development of new therapeutic agents for AIDS treatment.

Cite this article as:

Ribeiro Filho Jaime, de Sousa Falcao Heloina, Maria Batista Leonia, Maria Barbosa Filho Jose and Regina Piuvezam Marcia, Effects of Plant Extracts on HIV-1 Protease, Current HIV Research 2010; 8 (7) . https://dx.doi.org/10.2174/157016210793499204