Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model

Title: Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model

Volume: 4 Issue: 3

Author(s): Richard A. Peterson, David L. Krull, H. Roger Brown and Mark de Serres

Affiliation:

Keywords: Chimeric, drug metabolism, hepatocyte, humanized, liver, mouse

Abstract: Morphological evaluation of humanized chimeric mouse livers from the PhoenixBio® (uPA+/+/SCID) mouse model show robust replacement and expansion with human hepatocytes, however areas of human hepatocytes had prominent steatosis and a variable lack of sinusoids which was consistent with decreased hepatocellular perfusion and lacked bile canalicular formation between human and mouse hepatocytes.

Cite this article as:

A. Peterson Richard, L. Krull David, Roger Brown H. and de Serres Mark, Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model, Drug Metabolism Letters 2010; 4 (3) . https://dx.doi.org/10.2174/187231210791698456