Direct Nucleophilic 18F-Fluorination of Electron Rich Arenes: Present Limits of No-Carrier-Added Reactions

Heinz      H. Coenen; Johannes      Ermert

doi:10.2174/1874471011003030163

Abstract

In order to perform nucleophilic reactions of no-carrier-added [18F]fluoride also with arenes of high electron density an electrophilic center must be generated. This can be achieved by electrochemistry, decomposition of aryl-diazo-compounds, and use of aryl-iodonium compounds. Here, some general features and the application of those methods are described.

Keywords: Fluorine-18, radiofluorination, electron rich arenes, iodonium compounds, diazonium compounds, electrochemistry

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Current Radiopharmaceuticals

Title: Direct Nucleophilic 18F-Fluorination of Electron Rich Arenes: Present Limits of No-Carrier-Added Reactions

Volume: 3 Issue: 3

Author(s): Heinz H. Coenen and Johannes Ermert

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Keywords: Fluorine-18, radiofluorination, electron rich arenes, iodonium compounds, diazonium compounds, electrochemistry

Abstract: In order to perform nucleophilic reactions of no-carrier-added [18F]fluoride also with arenes of high electron density an electrophilic center must be generated. This can be achieved by electrochemistry, decomposition of aryl-diazo-compounds, and use of aryl-iodonium compounds. Here, some general features and the application of those methods are described.

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H. Coenen Heinz and Ermert Johannes, Direct Nucleophilic 18F-Fluorination of Electron Rich Arenes: Present Limits of No-Carrier-Added Reactions, Current Radiopharmaceuticals 2010; 3 (3) . https://dx.doi.org/10.2174/1874471011003030163