Recent Patents on the Pichia Pastoris Expression System: Expanding the Toolbox for Recombinant Protein Production

Title: Recent Patents on the Pichia Pastoris Expression System: Expanding the Toolbox for Recombinant Protein Production

Volume: 3 Issue: 3

Author(s): Monika Bollok, David Resina, Francisco Valero and Pau Ferrer

Affiliation:

Keywords: Pichia pastoris, recombinant protein production, AOX1 promoter, secretion helper factors, N-glycosylation pathway engineering

Abstract: Pichia pastoris is a widely used host system for heterologous protein expression both for basic research and industrial production purposes. Recent developments expanding the P. pastoris protein expression toolbox reflect the increasing interest in the application of yeast expression systems for protein-based pharmaceutical products, as an alternative to Escherichia coli and mammalian cell factories. The commonly used expression system for P. pastoris and, the recent patents relevant to the P. pastoris genetic toolbox for recombinant protein production are reviewed.

Cite this article as:

Bollok Monika, Resina David, Valero Francisco and Ferrer Pau, Recent Patents on the Pichia Pastoris Expression System: Expanding the Toolbox for Recombinant Protein Production, Recent Patents on Biotechnology 2009; 3 (3) . https://dx.doi.org/10.2174/187220809789389126