Abstract
By controlling mitochondrial membrane permeability, the Bcl-2 family of proteins plays a crucial role in the regulation of cell death. Members of this family are functionally categorized as either pro- or anti-apoptotic based on their ability to promote or inhibit mitochondrial-dependent cell death signals. The critical role of Bcl-2 family proteins in human diseases has made them the focus of intense research by the pharmaceutical industry and academia. Anti-apoptotic Bcl-2 homologues have been widely explored as potential therapeutic targets for anticancer therapy through the development of nucleic-acid and peptide-based inhibitory molecules. Recently, strategies for the development of peptides or polypeptides derived from specific Bcl-2 family members have also been devised. This paper provides a brief review of the most recent patents that have been published relating to this area.
Keywords: Apoptosis, Bcl-2 family, mitochondria, cancer therapy, functional nucleic acids, bioactive peptides
Recent Patents on DNA & Gene Sequences
Title: Novel Genetic and Peptide-Based Strategies Targeting the Bcl-2 Family, an Update
Volume: 3 Issue: 2
Author(s): Abdel Aouacheria
Affiliation:
Keywords: Apoptosis, Bcl-2 family, mitochondria, cancer therapy, functional nucleic acids, bioactive peptides
Abstract: By controlling mitochondrial membrane permeability, the Bcl-2 family of proteins plays a crucial role in the regulation of cell death. Members of this family are functionally categorized as either pro- or anti-apoptotic based on their ability to promote or inhibit mitochondrial-dependent cell death signals. The critical role of Bcl-2 family proteins in human diseases has made them the focus of intense research by the pharmaceutical industry and academia. Anti-apoptotic Bcl-2 homologues have been widely explored as potential therapeutic targets for anticancer therapy through the development of nucleic-acid and peptide-based inhibitory molecules. Recently, strategies for the development of peptides or polypeptides derived from specific Bcl-2 family members have also been devised. This paper provides a brief review of the most recent patents that have been published relating to this area.
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Cite this article as:
Aouacheria Abdel, Novel Genetic and Peptide-Based Strategies Targeting the Bcl-2 Family, an Update, Recent Patents on DNA & Gene Sequences 2009; 3 (2) . https://dx.doi.org/10.2174/187221509788654160
DOI https://dx.doi.org/10.2174/187221509788654160 |
Print ISSN 1872-2156 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3431 |
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