Pharmacokinetics and Metabolism of Diltiazem Following Multiple Doses:Comparing Normotensive Rat vs. Hypertensive Rat Models In vivo

Title: Pharmacokinetics and Metabolism of Diltiazem Following Multiple Doses:Comparing Normotensive Rat vs. Hypertensive Rat Models In vivo

Volume: 2 Issue: 2

Author(s): Pollen K.F. Yeung, Angelita Alcos, Jinglan Tang and William l. Casley

Affiliation:

Keywords: Metabolism, pharmacokinetics, diltiazem, rats, SHR

Abstract: In order to identify a suitable rodent model for preclinical study of calcium antagonists, pharmacokinetics and metabolism of diltiazem (DTZ) were compared in normotensive SD and hypertensive SHR rat models following multiple doses (5 mg/kg twice daily for 5 doses). Plasma concentrations of DTZ and its major metabolites appeared to be higher in the SHR than the SD rats, although the differences did not reach statistical significance (p > 0.05). The preliminary results suggest metabolism profile of DTZ in the SHR may be closer to humans than the SD rats and may be more preferred in pre-clinical drug development studies for DTZ.

Cite this article as:

Yeung K.F. Pollen, Alcos Angelita, Tang Jinglan and Casley l. William, Pharmacokinetics and Metabolism of Diltiazem Following Multiple Doses:Comparing Normotensive Rat vs. Hypertensive Rat Models In vivo, Drug Metabolism Letters 2008; 2 (2) . https://dx.doi.org/10.2174/187231208784040915