Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats

Hege      Wergedahl; Kjetil      Berge; Pavol      Bohov; Karl-Johan      Tronstad; Lise      Madsen; Rolf   K.   Berge

doi:10.2174/187231208784041013

Abstract

Increased oxidative stress was observed in obese Zucker rats. Treatment of obese rats with tetradecylthioacetic acid for 12 weeks increased the H2O2-production, but decreased plasma malondialdehyde, changed the serum fatty acid profile, increased liver fatty acid binding protein mRNA, and lowered serum insulin, thereby enhancing the antioxidant defense system.

Keywords: Obesity, peroxisome proliferation, antioxidant enzymes, hydrogen peroxide, α-tocopherol, malondialdehyde

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