Abstract
CYP3A isoforms account for about 30% of total hepatic P450s. Most statins have been accepted probes for CYP3A4. The metabolic ratio of atorvastatin/ortho-hydroxyatorvastatin showed a bimodal distribution with respect to metabolism of atorvastatin. These observations showed that the frequency of occurrence of the poor metabolizer phenotype is 2.4 % in the Gujarat subjects.
Keywords: Cytochrome P450, atorvastatin, phenotype, gujarati, CYP3A4
Drug Metabolism Letters
Title: Phenotyping of Cytochrome P450 3A Enzyme in Gujarat Population
Volume: 2 Issue: 1
Author(s): Ashutosh J. Jani, Shivprakash Rathnam and Anita A. Mehta
Affiliation:
Keywords: Cytochrome P450, atorvastatin, phenotype, gujarati, CYP3A4
Abstract: CYP3A isoforms account for about 30% of total hepatic P450s. Most statins have been accepted probes for CYP3A4. The metabolic ratio of atorvastatin/ortho-hydroxyatorvastatin showed a bimodal distribution with respect to metabolism of atorvastatin. These observations showed that the frequency of occurrence of the poor metabolizer phenotype is 2.4 % in the Gujarat subjects.
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Jani J. Ashutosh, Rathnam Shivprakash and Mehta A. Anita, Phenotyping of Cytochrome P450 3A Enzyme in Gujarat Population, Drug Metabolism Letters 2008; 2 (1) . https://dx.doi.org/10.2174/187231208783478416
DOI https://dx.doi.org/10.2174/187231208783478416 |
Print ISSN 1872-3128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-0758 |