Visualization of First-Pass Drug Metabolism of Terfenadine by MALDIImaging Mass Spectrometry

Title: Visualization of First-Pass Drug Metabolism of Terfenadine by MALDIImaging Mass Spectrometry

Volume: 2 Issue: 1

Author(s): Yunsheng Hsieh, Jiwen Chen, Ian Knemeyer, Lee Crossman and Walter A. Korfmacher

Affiliation:

Keywords: Imaging mass spectrometry, MALDI, first-pass metabolism

Abstract: The aim of this article is to focus on the implementation and the application of matrix-assisted laser desorption/ ionization-imaging mass spectrometric system (MALDI-IMS) to determine the disposition or biotransformation pathway of terfenadine and its active metabolite, fexofenadine in mouse and rat whole-body tissue sections. Whole-body MALDI-IMS data showed that the poor oral bioavailability of terfenadine was largely due to high first-pass metabolism in the intestines and the liver before the compound reached systemic circulation.

Cite this article as:

Hsieh Yunsheng, Chen Jiwen, Knemeyer Ian, Crossman Lee and Korfmacher A. Walter, Visualization of First-Pass Drug Metabolism of Terfenadine by MALDIImaging Mass Spectrometry, Drug Metabolism Letters 2008; 2 (1) . https://dx.doi.org/10.2174/187231208783478461