Biological Targets of Antitumor Indolocarbazoles Bearing a Sugar Moiety

Title: Biological Targets of Antitumor Indolocarbazoles Bearing a Sugar Moiety

Volume: 4 Issue: 6

Author(s): Michelle Prudhomme

Affiliation:

Keywords: indolocarbazoles, protein kinases, topoisomerase I, dna intercalators, antitumor agents

Abstract: Natural and synthetic indolocarbazole compounds have triggered considerable interest since the discovery in 1986 of the inhibitory properties of staurosporine toward protein kinase C (PKC). Later, it has been shown that indolocarbazole compounds may inhibit various kinases, such as cyclin dependent-kinases and / or topoisomerase I, someones behave only as DNA intercalators. In this review are presented various indolocarbazole compounds bearing a sugar moiety and their biological targets. The relevance of these targets to develop indolocarbazole compounds as potential antitumor agents is discussed.

Cite this article as:

Prudhomme Michelle, Biological Targets of Antitumor Indolocarbazoles Bearing a Sugar Moiety, Current Medicinal Chemistry - Anti-Cancer Agents 2004; 4 (6) . https://dx.doi.org/10.2174/1568011043352650