Abstract
Camptothecin (CPT) and its analogs are some of the most potent antitumor agents known. However, their poor water-solubility and high toxicity require changes of their physicochemical and biological characteristics. Active lactone forms have provoked interest in the utility of CPT and its analogs again. Macromolecular chemical modifications and nanotechnological formulations have been used to obtain improved systems of CPT-related compounds. In these systems, one of the most important concepts is the enhanced permeability and retention (EPR) effect. The outcomes obtained by these approaches are displayed by introducing concrete examples.
Keywords: camptothecin (cpt), analog, macromolecular chemical modification, nanotechnological formulation, enhanced permeability and retention (epr) effect
Current Drug Discovery Technologies
Title: Macromolecular and Nanotechnological Modification of Camptothecin and its Analogs to Improve the Efficacy
Volume: 2 Issue: 3
Author(s): Hiraku Onishi and Yoshiharu Machida
Affiliation:
Keywords: camptothecin (cpt), analog, macromolecular chemical modification, nanotechnological formulation, enhanced permeability and retention (epr) effect
Abstract: Camptothecin (CPT) and its analogs are some of the most potent antitumor agents known. However, their poor water-solubility and high toxicity require changes of their physicochemical and biological characteristics. Active lactone forms have provoked interest in the utility of CPT and its analogs again. Macromolecular chemical modifications and nanotechnological formulations have been used to obtain improved systems of CPT-related compounds. In these systems, one of the most important concepts is the enhanced permeability and retention (EPR) effect. The outcomes obtained by these approaches are displayed by introducing concrete examples.
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Cite this article as:
Onishi Hiraku and Machida Yoshiharu, Macromolecular and Nanotechnological Modification of Camptothecin and its Analogs to Improve the Efficacy, Current Drug Discovery Technologies 2005; 2 (3) . https://dx.doi.org/10.2174/1570163054866891
DOI https://dx.doi.org/10.2174/1570163054866891 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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