Synthesis of Cinnamide Dimers as Potential Antibacterial and Antifungal Agents

Title: Synthesis of Cinnamide Dimers as Potential Antibacterial and Antifungal Agents

Volume: 8 Issue: 10

Author(s): Ahmed Kamal, G. Ramakrishna, P. Raju, A. V. Subba Rao, Joveeta Joseph, B. Siddhardha and U. S.N. Murty

Affiliation:

Keywords: Antibacterial, Antifungal, Cinnamide dimers, Piperazine, antimicrobial activity, antifungal activity, methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant epidermidis (MRSE), vancomycin, VRE, enterococci, Crixivan, N-Boc piperazine, Aspergillus

Abstract: A series of new cinnamide dimers was synthesized (5a-6a) and evaluated for their antimicrobial and antifungal activity. All the compounds investigated have shown significant antimicrobial activity against gram-positive and gram-negative bacterial strains, as well as few fungal strains. The compounds having withdrawing group exhibited significant biological activity than their precursors. Moreover all the compounds containing electron withdrawing substituent showed good antimicrobial activity in comparison with the standards.

Cite this article as:

Kamal Ahmed, Ramakrishna G., Raju P., V. Subba Rao A., Joseph Joveeta, Siddhardha B. and S.N. Murty U., Synthesis of Cinnamide Dimers as Potential Antibacterial and Antifungal Agents, Letters in Drug Design & Discovery 2011; 8 (10) . https://dx.doi.org/10.2174/157018011797655205