Abstract
Stem cells – based therapy is one of the most promising therapeutic approaches for amyotrophic lateral sclerosis (ALS), which is a fatal neurodegenerative disease without cure. This paper reviews the most intriguing pre-clinical and clinical studies and reports the current status of knowledge regarding ALS pathogenesis, confronting it with stem cell applications and their effects. Here we summarize various therapeutic approaches with respect to different sources of stem cells and diverse administration routes. Observed slow down of the disease progression and acceptable side effects emerge as the solid basis for optimism regarding the potential of the stem cell therapy for ALS.
Keywords: cell transplantation, administration route, regenerative medicine, amyotrophic lateral sclerosis, stem cells, therapy, neural stem cells, mesenchymal stem cells, growth factors, rats, mice, clinical trial, delivery, dose, iPS, cell replacement
Current Signal Transduction Therapy
Title: The Therapeutic Potential of Stem Cells in Amyotrophic Lateral Sclerosis
Volume: 6 Issue: 3
Author(s): Dinko Mitrecic, Charles Nicaise, Srecko Gajovic and Roland Pochet
Affiliation:
Keywords: cell transplantation, administration route, regenerative medicine, amyotrophic lateral sclerosis, stem cells, therapy, neural stem cells, mesenchymal stem cells, growth factors, rats, mice, clinical trial, delivery, dose, iPS, cell replacement
Abstract: Stem cells – based therapy is one of the most promising therapeutic approaches for amyotrophic lateral sclerosis (ALS), which is a fatal neurodegenerative disease without cure. This paper reviews the most intriguing pre-clinical and clinical studies and reports the current status of knowledge regarding ALS pathogenesis, confronting it with stem cell applications and their effects. Here we summarize various therapeutic approaches with respect to different sources of stem cells and diverse administration routes. Observed slow down of the disease progression and acceptable side effects emerge as the solid basis for optimism regarding the potential of the stem cell therapy for ALS.
Export Options
About this article
Cite this article as:
Mitrecic Dinko, Nicaise Charles, Gajovic Srecko and Pochet Roland, The Therapeutic Potential of Stem Cells in Amyotrophic Lateral Sclerosis, Current Signal Transduction Therapy 2011; 6 (3) . https://dx.doi.org/10.2174/157436211797483985
DOI https://dx.doi.org/10.2174/157436211797483985 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Glitazones, PPAR-γ and Neuroprotection
Mini-Reviews in Medicinal Chemistry Neuronal High-Affinity Sodium-Dependent Glutamate Transporters (EAATs): Targets for the Development of Novel Therapeutics Against Neurodegenerative Diseases
Current Pharmaceutical Design The Stress Rheostat: An Interplay Between the Unfolded Protein Response (UPR) and Autophagy in Neurodegeneration
Current Molecular Medicine Tandem Repeat Peptide Strategy for the Design of Neurotrophic Factor Mimetics
CNS & Neurological Disorders - Drug Targets Mesenchymal Stromal Cell Secretome: Immunomodulation, Tissue Repair and Effects on Neurodegenerative Conditions
Current Stem Cell Research & Therapy Neurodegeneration and the Heat Shock Protein 70 Machinery: Implications for Therapeutic Development
Current Topics in Medicinal Chemistry Withania somnifera Phytochemicals Confer Neuroprotection by Inhibition of the Catalytic Domain of Human Matrix Metalloproteinase-9
Letters in Drug Design & Discovery Commentary: Multifactoriality of Amytrophic Lateral Sclerosis: Linking Unfolded Proteins to Oxidative Stress in Microglia
CNS & Neurological Disorders - Drug Targets Persistent Current Blockers of Voltage-Gated Sodium Channels: A Clinical Opportunity for Controlling Metastatic Disease
Recent Patents on Anti-Cancer Drug Discovery Meet Our Editorial Board Member
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) The Role of Iron Toxicity in Oxidative Stress-induced Cellular Degeneration in Down Syndrome: Protective Effects of Phenolic Antioxidants
Current Nutrition & Food Science Decreased Regenerative Capacity of Oligodendrocyte Progenitor Cells (NG2-Glia) in the Ageing Brain: A Vicious Cycle of Synaptic Dysfunction, Myelin Loss and Neuronal Disruption?
Current Alzheimer Research Targeting Tumor Necrosis Factor Alpha for Alzheimer’s Disease
Current Alzheimer Research Using Small Molecule GSK3β Inhibitors to Treat Inflammation
Current Medicinal Chemistry Use of Human Umbilical Cord Blood (HUCB) Cells to Repair the Damaged Brain
Current Neurovascular Research Expression and Function of the Endocannabinoid System in Glial Cells
Current Pharmaceutical Design Oxidant/Antioxidant Imbalance and the Risk of Alzheimer's Disease
Current Alzheimer Research Fish and Apoptosis: Studies in Disease and Pharmaceutical Design
Current Pharmaceutical Design Progress in Imaging Agents of Cell Apoptosis
Anti-Cancer Agents in Medicinal Chemistry The Biology of Neurotrophins, Signalling Pathways, and Functional Peptide Mimetics of Neurotrophins and their Receptors
CNS & Neurological Disorders - Drug Targets