Most Recent Developments and Modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan Derivatives

Title: Most Recent Developments and Modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan Derivatives

Volume: 11 Issue: 12

Author(s): L. Stavitskaya and A. Coop

Affiliation:

Keywords: Opioid agonist, opioid antagonist, 14-alkoxymorphinans, 14-amino-4,5-epoxymorphinan derivatives, 14-Oheterocyclic naltrexones, morphine, opiates, SAR, analgesics, 14-position

Abstract: The 14-position of natural opiates (e.g. morphine) are unsubstituted, however synthetic approaches have uncovered that functionalizing position 14 gives rise to a wide range of diverse activities. This review focuses on SAR of the position, with the aim of aiding in the search for opioid analgesics with improved clinical profiles.

Cite this article as:

Stavitskaya L. and Coop A., Most Recent Developments and Modifications of 14-alkylamino and 14-alkoxy-4,5-epoxymorphinan Derivatives, Mini-Reviews in Medicinal Chemistry 2011; 11 (12) . https://dx.doi.org/10.2174/138955711797247752