Synthesis and In Vitro Antitumor Activity of Novel Fluorine Containing Pyrazoles and Pyrazolines

Title: Synthesis and In Vitro Antitumor Activity of Novel Fluorine Containing Pyrazoles and Pyrazolines

Volume: 8 Issue: 9

Author(s): Ashish Sharma, Tabreskhan Pathan, Rhea Mohan and C. S. Ramaa

Affiliation:

Keywords: Breast cancer cell line, Cytotoxicity, Pyrazoles, Pyrazolines, Sulforhodamine B Assay, antitumor activity, radiotherapy, fluorine, antitubercular, antimalarial, nucleophilic centers, heterocycles, antidepressant, breast cancer, MCF7, vagal nerve

Abstract: Novel fluorine-containing pyrazolines (2a-2g) and pyrazoles (5a-5e) were synthesized and evaluated for their cytotoxicity in vitro in a panel of four human cancer cell lines using Sulforhodamine B (SRB) assay. Though the compounds showed varying degrees of cytotoxicity in different cell lines, it was noteworthy that the 4H pyrazoles (5a-5e) were distinguished by their potent and selective action against MCF7 breast cancer cell line.

Cite this article as:

Sharma Ashish, Pathan Tabreskhan, Mohan Rhea and S. Ramaa C., Synthesis and In Vitro Antitumor Activity of Novel Fluorine Containing Pyrazoles and Pyrazolines, Letters in Drug Design & Discovery 2011; 8 (9) . https://dx.doi.org/10.2174/157018011797200812

DOI https://dx.doi.org/10.2174/157018011797200812	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X