Abstract
Novel fluorine-containing pyrazolines (2a-2g) and pyrazoles (5a-5e) were synthesized and evaluated for their cytotoxicity in vitro in a panel of four human cancer cell lines using Sulforhodamine B (SRB) assay. Though the compounds showed varying degrees of cytotoxicity in different cell lines, it was noteworthy that the 4H pyrazoles (5a-5e) were distinguished by their potent and selective action against MCF7 breast cancer cell line.
Keywords: Breast cancer cell line, Cytotoxicity, Pyrazoles, Pyrazolines, Sulforhodamine B Assay, antitumor activity, radiotherapy, fluorine, antitubercular, antimalarial, nucleophilic centers, heterocycles, antidepressant, breast cancer, MCF7, vagal nerve
Letters in Drug Design & Discovery
Title: Synthesis and In Vitro Antitumor Activity of Novel Fluorine Containing Pyrazoles and Pyrazolines
Volume: 8 Issue: 9
Author(s): Ashish Sharma, Tabreskhan Pathan, Rhea Mohan and C. S. Ramaa
Affiliation:
Keywords: Breast cancer cell line, Cytotoxicity, Pyrazoles, Pyrazolines, Sulforhodamine B Assay, antitumor activity, radiotherapy, fluorine, antitubercular, antimalarial, nucleophilic centers, heterocycles, antidepressant, breast cancer, MCF7, vagal nerve
Abstract: Novel fluorine-containing pyrazolines (2a-2g) and pyrazoles (5a-5e) were synthesized and evaluated for their cytotoxicity in vitro in a panel of four human cancer cell lines using Sulforhodamine B (SRB) assay. Though the compounds showed varying degrees of cytotoxicity in different cell lines, it was noteworthy that the 4H pyrazoles (5a-5e) were distinguished by their potent and selective action against MCF7 breast cancer cell line.
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Cite this article as:
Sharma Ashish, Pathan Tabreskhan, Mohan Rhea and S. Ramaa C., Synthesis and In Vitro Antitumor Activity of Novel Fluorine Containing Pyrazoles and Pyrazolines, Letters in Drug Design & Discovery 2011; 8 (9) . https://dx.doi.org/10.2174/157018011797200812
DOI https://dx.doi.org/10.2174/157018011797200812 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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