One-Pot, Solvent Free Synthesis of Hantzsch 1, 4-Dihydropyridines Using β-Cyclodextrin as a Supramolecular Catalyst

Dipak      R. Patil; Dipak      S. Dalal

doi:10.2174/157017811796504891

Abstract

A novel, solvent free and efficient one pot synthesis of 1, 4-dihydropyridine derivatives was achieved in good yields via three component reaction of aldehydes, ethyl acetoacetate and ammonium acetate using inexpensive β- cyclodextrin as a supramolecular catalyst. The catalyst can be recovered and reused without loss of activity.

Keywords: 1, 4-dihydropyridine (1, 4-DHPs), hantzsch reaction, one pot condensation, β- Cyclodextrin (β-CD), aldehydes, acetoacetate, ethyl, ammonium, anti-inflammatory agent, bronchodilator

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Letters in Organic Chemistry

Title: One-Pot, Solvent Free Synthesis of Hantzsch 1, 4-Dihydropyridines Using β-Cyclodextrin as a Supramolecular Catalyst

Volume: 8 Issue: 7

Author(s): Dipak R. Patil and Dipak S. Dalal

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Keywords: 1, 4-dihydropyridine (1, 4-DHPs), hantzsch reaction, one pot condensation, β- Cyclodextrin (β-CD), aldehydes, acetoacetate, ethyl, ammonium, anti-inflammatory agent, bronchodilator

Abstract: A novel, solvent free and efficient one pot synthesis of 1, 4-dihydropyridine derivatives was achieved in good yields via three component reaction of aldehydes, ethyl acetoacetate and ammonium acetate using inexpensive β- cyclodextrin as a supramolecular catalyst. The catalyst can be recovered and reused without loss of activity.

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R. Patil Dipak and S. Dalal Dipak, One-Pot, Solvent Free Synthesis of Hantzsch 1, 4-Dihydropyridines Using β-Cyclodextrin as a Supramolecular Catalyst, Letters in Organic Chemistry 2011; 8 (7) . https://dx.doi.org/10.2174/157017811796504891