Green and One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin- 4(1H)-Ones Promoted by Citric Acid as Recoverable Catalyst in Water

Arash      Ghorbani-Choghamarani; Tahereh      Taghipour

doi:10.2174/157017811796505025

Abstract

Citric acid was used as green, non-toxic and reusable catalyst for the preparation of substituted 2,3- dihydroquinazolin-4(1H)ones in high purity and good yields via one-pot three-component reaction of isatoic anhydride with a variety of aldehydes and primary amines or ammonium acetate in water at 80 ° C.

Keywords: 2,3-Dihydroquinazolin-4(1H)-one, catalysis, citric acid, isatoic anhydride, multicomponent reaction, ammonium, acetate, water, amines, antibacterial

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Letters in Organic Chemistry

Title: Green and One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin- 4(1H)-Ones Promoted by Citric Acid as Recoverable Catalyst in Water

Volume: 8 Issue: 7

Author(s): Arash Ghorbani-Choghamarani and Tahereh Taghipour

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Keywords: 2,3-Dihydroquinazolin-4(1H)-one, catalysis, citric acid, isatoic anhydride, multicomponent reaction, ammonium, acetate, water, amines, antibacterial

Abstract: Citric acid was used as green, non-toxic and reusable catalyst for the preparation of substituted 2,3- dihydroquinazolin-4(1H)ones in high purity and good yields via one-pot three-component reaction of isatoic anhydride with a variety of aldehydes and primary amines or ammonium acetate in water at 80 ° C.

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Ghorbani-Choghamarani Arash and Taghipour Tahereh, Green and One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin- 4(1H)-Ones Promoted by Citric Acid as Recoverable Catalyst in Water, Letters in Organic Chemistry 2011; 8 (7) . https://dx.doi.org/10.2174/157017811796505025