A Novel Synthesis of Ibutilide Fumarate

Tao      Wang; Rui      Tian; Bin      Xiao; Yi      Shen; Hui      Zhou; Qingeng      Li

doi:10.2174/157017811796064412

Abstract

A novel protocol for the synthesis of Ibutilide Fumarate (raceme) was achieved from 2-pyrrolidinone with an overall yield of 15%. The core structure was constructed in one step based on Friedel-Crafts acylation with an acyl chloride containing an amino hydrochloride.

Keywords: Friedel-Crafts acylation, Ibutilide, synthesis, fumarate, antiarrhythmic, pyrrolidinone, repolarization, extravascular distribution, cardioversion, methylsulfonyl

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Letters in Organic Chemistry

Title: A Novel Synthesis of Ibutilide Fumarate

Volume: 8 Issue: 6

Author(s): Tao Wang, Rui Tian, Bin Xiao, Yi Shen, Hui Zhou and Qingeng Li

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Keywords: Friedel-Crafts acylation, Ibutilide, synthesis, fumarate, antiarrhythmic, pyrrolidinone, repolarization, extravascular distribution, cardioversion, methylsulfonyl

Abstract: A novel protocol for the synthesis of Ibutilide Fumarate (raceme) was achieved from 2-pyrrolidinone with an overall yield of 15%. The core structure was constructed in one step based on Friedel-Crafts acylation with an acyl chloride containing an amino hydrochloride.

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Wang Tao, Tian Rui, Xiao Bin, Shen Yi, Zhou Hui and Li Qingeng, A Novel Synthesis of Ibutilide Fumarate, Letters in Organic Chemistry 2011; 8 (6) . https://dx.doi.org/10.2174/157017811796064412