Synthesis of Vinylphosphonates and its First Exploration of Bioactivity

Title: Synthesis of Vinylphosphonates and its First Exploration of Bioactivity

Volume: 8 Issue: 6

Author(s): Sheng-Nan Li, Lan-Ting Xu, Yue Chen, Ju-Lian Li and Ling He

Affiliation:

Keywords: Vinylphosphonate, phosphonation, triethyl phosphite, B-nitro-alkene, microwave irradiation, carbonphosphor, enantioselective, Phosphorus-alkene bonds, organophosphorus, Horner-Wadsworth-Emmons reaction

Abstract: Phosphonation of β-nitro-alkene with triethyl phosphite was achieved under microwave irradiation using CH2Cl2 as the solvent in the absence of catalyst with moderate to high yields (up to 90%). This method of formation of carbonphosphor bonds is simple, mild, convenient and effective. Synchronously, a number of vinylphosphonates derivatives were synthesized and evaluated biologically preliminary.

Cite this article as:

Li Sheng-Nan, Xu Lan-Ting, Chen Yue, Li Ju-Lian and He Ling, Synthesis of Vinylphosphonates and its First Exploration of Bioactivity, Letters in Organic Chemistry 2011; 8 (6) . https://dx.doi.org/10.2174/157017811796064467