Interleukin-25 Negatively Controls Pathogenic Responses in the Gut

Title: Interleukin-25 Negatively Controls Pathogenic Responses in the Gut

Volume: 10 Issue: 3

Author(s): Eleonora Franze, Angelamaria Rizzo, Roberta Caruso, Francesco Pallone and Giovanni Monteleone

Affiliation:

Keywords: IL-25, IBD, Th1, Th17, TNF-, IFN-, NK cells, gut, gut immune, cytokines

Abstract: Although interleukin-25 (IL-25) has been traditionally considered as a cytokine involved in T helper (Th) 2 cell-associated allergic diseases and host defence against helminthic parasites, recent studies have shown that IL-25 exerts negative effects on the initiation and progression of Th1/Th17-mediated pathologies. This later function of IL-25 is particularly evident at the gut level, where IL-25 could contribute to attenuate tissue-damaging immune responses. These new and exciting pre-clinical observations suggest that therapeutic interventions aimed at enhancing IL-25 activity could be useful in the management of patients with chronic gut inflammation.

Cite this article as:

Franze Eleonora, Rizzo Angelamaria, Caruso Roberta, Pallone Francesco and Monteleone Giovanni, Interleukin-25 Negatively Controls Pathogenic Responses in the Gut, Inflammation & Allergy - Drug Targets (Discontinued) 2011; 10 (3) . https://dx.doi.org/10.2174/187152811795564028