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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Solvent-Free Biginelli Reaction: A Green Method for the Synthesis of 3,4-Dihydropyrimidin-2-ones Catalyzed by Protic Acids in Large-Scale

Author(s): Yangyun Wang, Jipan Yu, Haohao Yang, Zhiwei Miao and Ruyu Chen

Volume 8, Issue 4, 2011

Page: [264 - 267] Pages: 4

DOI: 10.2174/157017811795371386

Price: $65

Abstract

An environmentally benign Biginelli reaction for the large-scale preparation of substituted 3,4- dihydropyrimidin-2(1H)-ones using protic acids as a catalyst has been achieved. These mechanochemical reactions proceed efficiently in the absence of organic solvent, with the assistance of infrared lamp irradiation.

Keywords: Biginelli reaction, 3,4-dihydropyrimidin-2-ones, solvent-free reaction, large-scale, mechanochemical reaction, toxicity, dicarbonyl, dihydropyrimidine, aldehyde, carboxylate


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