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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

The First Total Synthesis of Tarennane, a Potent Antioxidant Chalcone Constituent from Tarenna Attenuate or Magnolia Officinalis

Author(s): Jincheng Yang, Tao Yang, Youfu Luo, Jun He, Jianyou Shi and Aihua Peng

Volume 8, Issue 4, 2011

Page: [258 - 263] Pages: 6

DOI: 10.2174/157017811795371368

Price: $65

Abstract

The convergent total synthesis of tarennane has been accomplished in six steps starting from commercially available phloroglucinol and guaiacol; the key step of the synthesis relies on a highly regioselective Heck reaction applying iodophenol and PdCl2(PPh3)2.

Keywords: Tarennane, total synthesis, heck reaction, antioxidant activity, Helicobacter pylori, Alpinia rafflesiana, Cardamonin, ketone, Magnolianone, tetrabutylammonium


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