Mechanisms of Bone Erosion in Chronic Gout: Lessons Learned from Other Erosive Arthropathies

Title: Mechanisms of Bone Erosion in Chronic Gout: Lessons Learned from Other Erosive Arthropathies

Volume: 7 Issue: 2

Author(s): Ashika Chhana and Nicola Dalbeth

Affiliation:

Keywords: Gout, bone, erosion, osteoclast, osteoblast, monosodium urate, pro-inflammatory cytokines, psoriatic arthritis, TNF transgenic, TNF-inhibition

Abstract: Gout is an inflammatory arthritis caused by deposition of monosodium urate (MSU) monohydrate crystals within the joint. Bone erosion is a frequent manifestation of chronic tophaceous gout, and leads to joint damage and deformity, with subsequent disability. This review summarises current understanding of bone remodelling, bone erosion in other erosive arthropathies and related conditions, and bone erosion in chronic gout. In particular, recent research implicating tophus invasion into bone and disordered osteoclastogenesis in the pathogenesis of bone erosion in gout is emphasised.

Cite this article as:

Chhana Ashika and Dalbeth Nicola, Mechanisms of Bone Erosion in Chronic Gout: Lessons Learned from Other Erosive Arthropathies, Current Rheumatology Reviews 2011; 7 (2) . https://dx.doi.org/10.2174/157339711795304979

DOI https://dx.doi.org/10.2174/157339711795304979	Print ISSN 1573-3971
Publisher Name Bentham Science Publisher	Online ISSN 1875-6360