Abstract
Genes showing copy number variation have been the subject of much study in recent years. Copy number variation has been found to be surprisingly common among humans. As much as 12% of the human genome is polymorphic in copy number and this can disrupt genes and alter gene dosage to influence gene expression, phenotypic variation and adaptation, but little is known about the significance of these copy number polymorphic genes. On-line databases, Complex Networks software, Gene Ontologies (GOs) analysis web servers, and other Bioinformatics tools may be very useful in this branch. In this sense, the present work reviews some bioinformatics concepts and previous studies related to Complex networks, GOs, and related methods that can be used for the study of Copy Number Polymorphic regions. The second objective of the envisaged work was to trace the divergence of human genomes in copy number variant genes and ascertain three conditions disease pathways and Functional Categories with Whole Genome TilePath (WGTP) array and 500K early access (500KEA) array data. These tests were performed to see significant departures from the divergence/ polymorphism ratio. The analysis of genes from WGTP and 500KEA gave the evidence for reciprocal disease and their pathways.
Keywords: Complex networks, gene ontology, KEGG, CNV, human genome, Whole Genome TilePath, Cell membrane, protein phosphatase, OMIM Disease, Hypothyroidism, Celiac disease, Egf-like domain, Schizophrenia
Current Bioinformatics
Title: Bioinformatics Analysis of Functional Relations Between CNPs Regions
Volume: 6 Issue: 1
Author(s): Kirtan Dave and Atreyi Banerjee
Affiliation:
Keywords: Complex networks, gene ontology, KEGG, CNV, human genome, Whole Genome TilePath, Cell membrane, protein phosphatase, OMIM Disease, Hypothyroidism, Celiac disease, Egf-like domain, Schizophrenia
Abstract: Genes showing copy number variation have been the subject of much study in recent years. Copy number variation has been found to be surprisingly common among humans. As much as 12% of the human genome is polymorphic in copy number and this can disrupt genes and alter gene dosage to influence gene expression, phenotypic variation and adaptation, but little is known about the significance of these copy number polymorphic genes. On-line databases, Complex Networks software, Gene Ontologies (GOs) analysis web servers, and other Bioinformatics tools may be very useful in this branch. In this sense, the present work reviews some bioinformatics concepts and previous studies related to Complex networks, GOs, and related methods that can be used for the study of Copy Number Polymorphic regions. The second objective of the envisaged work was to trace the divergence of human genomes in copy number variant genes and ascertain three conditions disease pathways and Functional Categories with Whole Genome TilePath (WGTP) array and 500K early access (500KEA) array data. These tests were performed to see significant departures from the divergence/ polymorphism ratio. The analysis of genes from WGTP and 500KEA gave the evidence for reciprocal disease and their pathways.
Export Options
About this article
Cite this article as:
Dave Kirtan and Banerjee Atreyi, Bioinformatics Analysis of Functional Relations Between CNPs Regions, Current Bioinformatics 2011; 6 (1) . https://dx.doi.org/10.2174/157489311795222329
DOI https://dx.doi.org/10.2174/157489311795222329 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Respiratory Syncytial Virus (RSV) Prevention and Treatment: Past, Present, and Future
Cardiovascular & Hematological Agents in Medicinal Chemistry Epigenetic Regulation in Particulate Matter-Mediated Cardiopulmonary Toxicities: A Systems Biology Perspective
Current Pharmacogenomics and Personalized Medicine Is the Vascular System a Main Target for Thyroid Hormones? From Molecular and Biochemical Findings to Clinical Perspectives
Current Vascular Pharmacology Atypical Takotsubo Cardiomyopathy with Hypokinetic Left Mid-ventricle and Apical Wall Sparing: A Case Report and Literature Review
Current Cardiology Reviews Apoptosis and Oxidative Stress-Related Diseases: The p66Shc Connection
Current Molecular Medicine Potential Role of Rho Kinase Inhibitors in Combating Diabetes-Related Complications Including Diabetic Neuropathy-A Review
Current Diabetes Reviews MicroRNAs: Novel Diagnostic and Prognostic Biomarkers in Atherosclerosis
Current Topics in Medicinal Chemistry Adult Stem Cells and Skeletal Muscle Regeneration
Current Gene Therapy Designing Novel Therapies Against Sarcomas in the Era of Personalized Medicine and Economic Crisis
Current Pharmaceutical Design Lipid Lowering Agents and the Endothelium: An Update after 4 Years
Current Vascular Pharmacology Cardiac Remodeling and Exercise Training in Hypertension
Current Hypertension Reviews Diet-Derived Phytochemicals: From Cancer Chemoprevention to Cardio-Oncological Prevention
Current Drug Targets What is Tobacco Smoke? Sociocultural Dimensions of the Association with Cardiovascular Risk
Current Pharmaceutical Design The Role of Nitro (NO<sub>2</sub>-), Chloro (Cl), and Fluoro (F) Substitution in the Design of Antileishmanial and Antichagasic Compounds
Current Drug Targets The Ubiquitin-Proteasome Pathway and Resistance Mechanisms Developed Against the Proteasomal Inhibitors in Cancer Cells
Current Drug Targets Microcirculation and Heart Failure
Current Pharmaceutical Design The Fundamental Role of Stress Echo in Evaluating Coronary Artery Disease in Specific Patient Populations
Current Vascular Pharmacology Biomarkers in Cardiomyopathies and Prediction of Sudden Cardiac Death
Current Pharmaceutical Biotechnology Bariatric Surgery and it Effects on the Respiratory System
Current Respiratory Medicine Reviews Immunoglobulin Therapy, Myocardial Diseases and Atherosclerosis:Recent Experimental and Clinical Studies
Current Cardiology Reviews