Abstract
A novel synthetic procedure for a series of 4-Aryl-3-phenyl-6,7,8,9-tetrahydro- benzothieno[3,2- f][1,4]oxazepin-5(4H)-one 8a-s derivatives had been described. Six compounds 8a,b,h,j,m,s were selected and submitted to pharmacological evaluation for anxiolytic activity in the open field test. All the test compounds except 8b significantly reduced the exploratory activity and the emotionality of the rats in the open-field. These inhibitory results are in agreement with the effect of reference standard chlorpromazine as a tranquillizer and anxiolytic in the same conditions.
Keywords: Synthesis, 5-Oxo-1, 4-Oxazepine derivatives, Open field test, Anxiolytic activity
Letters in Drug Design & Discovery
Title: Synthesis and Anxiolytic Activity of Some Novel 5-oxo-1, 4-oxazepine Derivatives
Volume: 8 Issue: 4
Author(s): Bothiana A. AbdelFattah, Maha M.A. Khalifa, Hend El-Sehrawi, Eman Fayed, Ashraf Bayoumi and Makarem Said
Affiliation:
Keywords: Synthesis, 5-Oxo-1, 4-Oxazepine derivatives, Open field test, Anxiolytic activity
Abstract: A novel synthetic procedure for a series of 4-Aryl-3-phenyl-6,7,8,9-tetrahydro- benzothieno[3,2- f][1,4]oxazepin-5(4H)-one 8a-s derivatives had been described. Six compounds 8a,b,h,j,m,s were selected and submitted to pharmacological evaluation for anxiolytic activity in the open field test. All the test compounds except 8b significantly reduced the exploratory activity and the emotionality of the rats in the open-field. These inhibitory results are in agreement with the effect of reference standard chlorpromazine as a tranquillizer and anxiolytic in the same conditions.
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Cite this article as:
A. AbdelFattah Bothiana, M.A. Khalifa Maha, El-Sehrawi Hend, Fayed Eman, Bayoumi Ashraf and Said Makarem, Synthesis and Anxiolytic Activity of Some Novel 5-oxo-1, 4-oxazepine Derivatives, Letters in Drug Design & Discovery 2011; 8 (4) . https://dx.doi.org/10.2174/157018011794839448
DOI https://dx.doi.org/10.2174/157018011794839448 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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