Abstract
We report the initial results of our study into a series of thiosemicarbazone-based compounds as potential inhibitors of estrone sulfatase (ES). The results show the compounds to be weak inhibitors of ES in comparison to the standard estrone-3-O-sulfamate used within the study and which possessed 98% inhibition under similar conditions.
Keywords: Estrone sulfatase, Inhibition, Breast cancer, Thiosemicarbazones, Non-steroidal, Non-competitive inhibition
Letters in Drug Design & Discovery
Title: Synthesis and Biological Evaluation of a Range of Thiosemicarbazone - Based Compounds as Potential Inhibitors of Estrone Sulfatase (ES)
Volume: 8 Issue: 3
Author(s): Amit Kumar, Sukriti Singh, Hadi Bordbar, Timothy Cartledge and Sabbir Ahmed
Affiliation:
Keywords: Estrone sulfatase, Inhibition, Breast cancer, Thiosemicarbazones, Non-steroidal, Non-competitive inhibition
Abstract: We report the initial results of our study into a series of thiosemicarbazone-based compounds as potential inhibitors of estrone sulfatase (ES). The results show the compounds to be weak inhibitors of ES in comparison to the standard estrone-3-O-sulfamate used within the study and which possessed 98% inhibition under similar conditions.
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Cite this article as:
Kumar Amit, Singh Sukriti, Bordbar Hadi, Cartledge Timothy and Ahmed Sabbir, Synthesis and Biological Evaluation of a Range of Thiosemicarbazone - Based Compounds as Potential Inhibitors of Estrone Sulfatase (ES), Letters in Drug Design & Discovery 2011; 8 (3) . https://dx.doi.org/10.2174/157018011794578231
DOI https://dx.doi.org/10.2174/157018011794578231 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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