Abstract
Pleiotropic effects of therapeutic statins have been frequently reported. The role of p38 MAP kinase has been advanced. In this paper, atorvastatin (containing a terphenylic system), rosuvastatin and fluvastatin, which are important drugs of the statin class, were docked into the active site of p38 MAP kinase where the selective and highly potent inhibitor SB 203580, a fluoro-phenyl pyridinylimidazole derivative, possessing a terphenylic system, binds. The protein-statin complexes near the ATP binding pocket reinforce the hypothesis of p38 MAP kinase as one possible molecular target for statin drugs.
Keywords: Molecular docking, p38 MAP kinase, Pleiotropic effects, Statins
Letters in Drug Design & Discovery
Title: A Theoretical Investigation on the Pleiotropic Effects of Statins as p38 MAP Kinase Ligands
Volume: 7 Issue: 8
Author(s): Carla M.S. Menezes, Carolina M. Avila and Eliezer J. Barreiro
Affiliation:
Keywords: Molecular docking, p38 MAP kinase, Pleiotropic effects, Statins
Abstract: Pleiotropic effects of therapeutic statins have been frequently reported. The role of p38 MAP kinase has been advanced. In this paper, atorvastatin (containing a terphenylic system), rosuvastatin and fluvastatin, which are important drugs of the statin class, were docked into the active site of p38 MAP kinase where the selective and highly potent inhibitor SB 203580, a fluoro-phenyl pyridinylimidazole derivative, possessing a terphenylic system, binds. The protein-statin complexes near the ATP binding pocket reinforce the hypothesis of p38 MAP kinase as one possible molecular target for statin drugs.
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M.S. Menezes Carla, M. Avila Carolina and J. Barreiro Eliezer, A Theoretical Investigation on the Pleiotropic Effects of Statins as p38 MAP Kinase Ligands, Letters in Drug Design & Discovery 2010; 7 (8) . https://dx.doi.org/10.2174/157018010792062812
DOI https://dx.doi.org/10.2174/157018010792062812 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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