Abstract
A bioassay oriented fractionation of Gloeophyllum odoratum dry extract has led to the isolation of three active fractions. On the basis of spectroscopic data, MS spectroscopy and microanalysis a new tetracyclic triterpene: 3α- hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, together with two known ones: trametenolic acid and 15α- hydroxytrametenolic acid, have been isolated, identified and proved to selectively inhibit thrombin but not trypsin.
Keywords: Gloeophyllum odoratum, 3α-Hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, Inhibitor, Thrombin, Triterpenes, Trypsin
Letters in Drug Design & Discovery
Title: Triterpenes from Gloeophyllum odoratum as Potential Leads Towards Potent Thrombin Inhibitors
Volume: 7 Issue: 7
Author(s): Francesca Cateni, Vittorio Lucchini, Marko Anderluh, Paolo Martinuzzi, Marina Zacchigna, Andrej Piltaver and Bojan Doljak
Affiliation:
Keywords: Gloeophyllum odoratum, 3α-Hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, Inhibitor, Thrombin, Triterpenes, Trypsin
Abstract: A bioassay oriented fractionation of Gloeophyllum odoratum dry extract has led to the isolation of three active fractions. On the basis of spectroscopic data, MS spectroscopy and microanalysis a new tetracyclic triterpene: 3α- hydroxy-12β-acetoxy-lanosta-8,24-dien-29-oic acid, together with two known ones: trametenolic acid and 15α- hydroxytrametenolic acid, have been isolated, identified and proved to selectively inhibit thrombin but not trypsin.
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Cateni Francesca, Lucchini Vittorio, Anderluh Marko, Martinuzzi Paolo, Zacchigna Marina, Piltaver Andrej and Doljak Bojan, Triterpenes from Gloeophyllum odoratum as Potential Leads Towards Potent Thrombin Inhibitors, Letters in Drug Design & Discovery 2010; 7 (7) . https://dx.doi.org/10.2174/157018010791526340
DOI https://dx.doi.org/10.2174/157018010791526340 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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