Design, Synthesis and In Vivo Evaluation of Sulfhydryl β-D-Glucose Cholesterols as Ligands for Brain Targeting Liposomes

Title: Design, Synthesis and In Vivo Evaluation of Sulfhydryl β-D-Glucose Cholesterols as Ligands for Brain Targeting Liposomes

Volume: 7 Issue: 4

Author(s): Wei Fan, Chengyi Yan, Shan Qian, Nian Yao, Lei Tang and Yong Wu

Affiliation:

Keywords: Blood-brain barrier, Liposome ligands, GLUT1, Brain-targeted delivery, Synthesis, Tegafur

Abstract: A novel sulfhydryl-β-D-glucose cholesterol 10a-10f as ligand for brain targeting liposomes was designed and synthesized. 10e was applied to the preparation of liposomal delivery system for achieving the brain-targeted delivery of the model drug tegafur in mice utilizing the glucose transporter member 1 (GLUT1). The results suggest the feasibility to enhance liposomes ability of delivering drug to brain by using the designed compound as liposome ligands.

Cite this article as:

Fan Wei, Yan Chengyi, Qian Shan, Yao Nian, Tang Lei and Wu Yong, Design, Synthesis and In Vivo Evaluation of Sulfhydryl β-D-Glucose Cholesterols as Ligands for Brain Targeting Liposomes, Letters in Drug Design & Discovery 2010; 7 (4) . https://dx.doi.org/10.2174/157018010790945788