Synthesis and Cytotoxic Evaluation of Disubstituted N-Acylhydrazones Pyrazinecarbohydrazide Derivatives

Title: Synthesis and Cytotoxic Evaluation of Disubstituted N-Acylhydrazones Pyrazinecarbohydrazide Derivatives

Volume: 7 Issue: 4

Author(s): Marcelle de L. Ferreira, Andre L.P. Candea, Maria das Gracas M. de O. Henriques, Carlos R. Kaiser, Camilo H. da S. Lima and Marcus V.N. de Souza

Affiliation:

Keywords: Pyrazine, N-acylhydrazones, Tuberculosis, Drugs

Abstract: A series of seventeen disubstituted N-acylhydrazone pyrazinecarbohydrazide (4-20) have been synthesized and evaluated for their cell viabilities, were compared to another monosubstituted derivatives previously synthesized by us. This study indicated that the position and nature of the substituents in the aromatic ring influence the cytotoxicity of this series.

Cite this article as:

de L. Ferreira Marcelle, Candea L.P. Andre, de O. Henriques M. Maria das Gracas, Kaiser R. Carlos, da S. Lima H. Camilo and de Souza V.N. Marcus, Synthesis and Cytotoxic Evaluation of Disubstituted N-Acylhydrazones Pyrazinecarbohydrazide Derivatives, Letters in Drug Design & Discovery 2010; 7 (4) . https://dx.doi.org/10.2174/157018010790945814

DOI https://dx.doi.org/10.2174/157018010790945814	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X