An Efficient Method for One-Pot Reductive Cleavage of Acetals to Primary Alcohols Using a Bimetal Redox Couple CoCl2.6H2O-Zn

Kuladip      Sarma; Amrit      Goswami

doi:10.2174/157017809789869456

Abstract

Acyclic or cyclic O,O-acetals and O,S-acetals underwent reductive cleavage to give primary alcohols efficiently on treatment with Zn-CoCl2.6H2O-bimetal redox system in dry tetrahydrofuran at ambient temperature to give good to excellent yields.

Keywords: Alcohols, acetals, bimetal redox system, deprotection, hydroxy ether, reductive cleavage

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Letters in Organic Chemistry

Title: An Efficient Method for One-Pot Reductive Cleavage of Acetals to Primary Alcohols Using a Bimetal Redox Couple CoCl2.6H2O-Zn

Volume: 6 Issue: 7

Author(s): Kuladip Sarma and Amrit Goswami

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Keywords: Alcohols, acetals, bimetal redox system, deprotection, hydroxy ether, reductive cleavage

Abstract: Acyclic or cyclic O,O-acetals and O,S-acetals underwent reductive cleavage to give primary alcohols efficiently on treatment with Zn-CoCl2.6H2O-bimetal redox system in dry tetrahydrofuran at ambient temperature to give good to excellent yields.

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Sarma Kuladip and Goswami Amrit, An Efficient Method for One-Pot Reductive Cleavage of Acetals to Primary Alcohols Using a Bimetal Redox Couple CoCl2.6H2O-Zn, Letters in Organic Chemistry 2009; 6 (7) . https://dx.doi.org/10.2174/157017809789869456