Ligand-Free Cu-Catalyzed Cyanation of Aryl Halides with K4[Fe(CN)6] in Water

Yunlai      Ren; Shuang      Zhao; Xinzhe      Tian; Zhifei      Liu; Jianji      Wang; Weiping      Yin

doi:10.2174/157017809789869573

Abstract

A simple methodology for Cu-catalyzed cyanation of aryl halides with K4[Fe(CN)6] was developed with water as the solvent in conjunction with ligand-free Cu(OAc)2·H2O as the catalyst. The suggested methodology is applicable to cyanation of a wide range of aryl iodides and activated aryl bromides, and allows the catalyst to be reused six times with a very slight change in the catalytic activity.

Keywords: Cyanation, aryl halide, ligand-free catalyst, water solvent

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Letters in Organic Chemistry

Title: Ligand-Free Cu-Catalyzed Cyanation of Aryl Halides with K4[Fe(CN)6] in Water

Volume: 6 Issue: 7

Author(s): Yunlai Ren, Shuang Zhao, Xinzhe Tian, Zhifei Liu, Jianji Wang and Weiping Yin

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Keywords: Cyanation, aryl halide, ligand-free catalyst, water solvent

Abstract: A simple methodology for Cu-catalyzed cyanation of aryl halides with K4[Fe(CN)6] was developed with water as the solvent in conjunction with ligand-free Cu(OAc)2·H2O as the catalyst. The suggested methodology is applicable to cyanation of a wide range of aryl iodides and activated aryl bromides, and allows the catalyst to be reused six times with a very slight change in the catalytic activity.

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Ren Yunlai, Zhao Shuang, Tian Xinzhe, Liu Zhifei, Wang Jianji and Yin Weiping, Ligand-Free Cu-Catalyzed Cyanation of Aryl Halides with K4[Fe(CN)6] in Water, Letters in Organic Chemistry 2009; 6 (7) . https://dx.doi.org/10.2174/157017809789869573