Synthesis and Biochemical Evaluation of a Series of Methanesulfonate Derivatives of 4-Hydroxyphenyl Ketone as Probes of the Active Site of Type 3 OF 17β-Hydroxysteroid Dehydrogenase Family of Enzymes

Title: Synthesis and Biochemical Evaluation of a Series of Methanesulfonate Derivatives of 4-Hydroxyphenyl Ketone as Probes of the Active Site of Type 3 OF 17β-Hydroxysteroid Dehydrogenase Family of Enzymes

Volume: 6 Issue: 7

Author(s): Kruti Shah, Moniola S. Olusanjo, Tim Cartledge, Caroline P. Owen and Sabbir Ahmed

Affiliation:

Keywords: 17β-hydroxysteroid dehydrogenase, Type 3, Androgen ablation, Enzyme inhibition, Methanesulfonate

Abstract: We report the synthesis, evaluation and rationalisation of the inhibitory activity of a series of compounds as probes of the active site of the type 3 of 17β-hydroxysteroid dehydrogenase (17β-HSD3). Results have provided invaluable insight into the active site (as well as supporting the previously reported model) of 17β-HSD3.

Cite this article as:

Shah Kruti, Olusanjo S. Moniola, Cartledge Tim, Owen P. Caroline and Ahmed Sabbir, Synthesis and Biochemical Evaluation of a Series of Methanesulfonate Derivatives of 4-Hydroxyphenyl Ketone as Probes of the Active Site of Type 3 OF 17β-Hydroxysteroid Dehydrogenase Family of Enzymes, Letters in Drug Design & Discovery 2009; 6 (7) . https://dx.doi.org/10.2174/157018009789108259

DOI https://dx.doi.org/10.2174/157018009789108259	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X