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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Regulation of Endochondral Ossification by Osteogenic Growth Peptide CTerminal Pentapeptide [OGP(10-14)]

Author(s): Zhixin Chen, Min Chang, Yali Peng, Li Zhao, Yurui Zhan, Lijing Wang and Rui Wang

Volume 16, Issue 9, 2009

Page: [1074 - 1080] Pages: 7

DOI: 10.2174/092986609789055395

Price: $65

Abstract

In neonatal rat metatarsal organ culture, a bell-shaped dose-related curve in length of mineralized area, increases in the height of proliferative and hypertrophic zones, in the number of hypertrophic chondrocyte and in the amount of Runx2 mRNA, were revealed after treatment with OGP(10-14). We conclude that OGP(10-14) accelerates bone growth.

Keywords: OGP(10-14), Regulation, Endochondral ossification


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