ABC Transporters as Potential Targets for Modulation of Drug Resistance

Title: ABC Transporters as Potential Targets for Modulation of Drug Resistance

Volume: 9 Issue: 9

Author(s): L. Gatti, G. L. Beretta, G. Cossa, F. Zunino and P. Perego

Affiliation:

Keywords: ATP binding cassette transporters, antitumor drugs, modulators

Abstract: ATP binding cassette transporters are implicated in multidrug resistant phenotypes of tumor cells and may be cancer stem cell markers. Inhibitors of drug efflux pumps represent an emerging group of potentially useful agents for the improvement of antitumor therapy. Here we provide an overview of drug transporter functions and modulation.

Cite this article as:

Gatti L., Beretta L. G., Cossa G., Zunino F. and Perego P., ABC Transporters as Potential Targets for Modulation of Drug Resistance, Mini-Reviews in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/138955709788922656