Synthesis and Conformational Preferences of Novel Steroidal 16-Spiro-1,3,2-Dioxaphosphorinanes

Eva      Frank; Laszlo      Sipos; Janos      Wolfling; Gyula      Schneider

doi:10.2174/157017809788489927

Abstract

The diastereomeric pairs a and b of novel 16-spiro-dioxaphosphorinanes 3-11 were synthesised via the phosphorylation of 16,16-bis(hydroxymethyl)estrone 3-methyl ether (1) and its 17β-hydroxy analogue (2) and their stereostructures were investigated by different NMR methods.

Keywords: Steroids, spiro compounds, phosphorylations, dioxaphosphorinanes, stereostructure

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Letters in Organic Chemistry

Title: Synthesis and Conformational Preferences of Novel Steroidal 16-Spiro-1,3,2-Dioxaphosphorinanes

Volume: 6 Issue: 4

Author(s): Eva Frank, Laszlo Sipos, Janos Wolfling and Gyula Schneider

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Keywords: Steroids, spiro compounds, phosphorylations, dioxaphosphorinanes, stereostructure

Abstract: The diastereomeric pairs a and b of novel 16-spiro-dioxaphosphorinanes 3-11 were synthesised via the phosphorylation of 16,16-bis(hydroxymethyl)estrone 3-methyl ether (1) and its 17β-hydroxy analogue (2) and their stereostructures were investigated by different NMR methods.

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Frank Eva, Sipos Laszlo, Wolfling Janos and Schneider Gyula, Synthesis and Conformational Preferences of Novel Steroidal 16-Spiro-1,3,2-Dioxaphosphorinanes, Letters in Organic Chemistry 2009; 6 (4) . https://dx.doi.org/10.2174/157017809788489927