Abstract
For many years, a pathological immune response has been implicated in the development of chronic pancreatitis. However, only in the last decade autoimmune pancreatitis (AIP) has been recognized as a distinct entity with typical histopathological and immunological findings. AIP is frequently associated with other autoimmune diseases, such as Sjogrens syndrome, sclerosing extra-hepatic cholangitis and retroperitoneal fibrosis. Although AIP is rare, improved diagnostics is of significant clinical interest because of the prompt response to steroid treatment. In this review, we describe the characteristic features of AIP and focus on the molecular pathogenesis of the disease.
Keywords: Autoimmune pancreatitis, molecular pathogenesis
Current Pharmaceutical Design
Title: Molecular Characteristics of Autoimmune Pancreatitis
Volume: 12 Issue: 29
Author(s): Robert Jaster and Jorg Emmrich
Affiliation:
Keywords: Autoimmune pancreatitis, molecular pathogenesis
Abstract: For many years, a pathological immune response has been implicated in the development of chronic pancreatitis. However, only in the last decade autoimmune pancreatitis (AIP) has been recognized as a distinct entity with typical histopathological and immunological findings. AIP is frequently associated with other autoimmune diseases, such as Sjogrens syndrome, sclerosing extra-hepatic cholangitis and retroperitoneal fibrosis. Although AIP is rare, improved diagnostics is of significant clinical interest because of the prompt response to steroid treatment. In this review, we describe the characteristic features of AIP and focus on the molecular pathogenesis of the disease.
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Cite this article as:
Jaster Robert and Emmrich Jorg, Molecular Characteristics of Autoimmune Pancreatitis, Current Pharmaceutical Design 2006; 12 (29) . https://dx.doi.org/10.2174/138161206778559812
DOI https://dx.doi.org/10.2174/138161206778559812 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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