One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate

Dina      Scarpi; Ernesto      G. Occhiato; Antonio      Guarna; Valerio      Borzatta

doi:10.2174/157017810791130667

Abstract

A new method is reported for the preparation of 2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester, a key intermediate in the synthesis of Tadalafil which is used for the treatment of male erectile dysfunction, via one-pot esterification and Pictet-Spengler reaction.

Keywords: Pictet-Spengler, esterification, isomerization, Tadalafil

« Previous Next »

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate

Volume: 7 Issue: 4

Author(s): Dina Scarpi, Ernesto G. Occhiato, Antonio Guarna and Valerio Borzatta

Affiliation:

Keywords: Pictet-Spengler, esterification, isomerization, Tadalafil

Abstract: A new method is reported for the preparation of 2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester, a key intermediate in the synthesis of Tadalafil which is used for the treatment of male erectile dysfunction, via one-pot esterification and Pictet-Spengler reaction.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Scarpi Dina, G. Occhiato Ernesto, Guarna Antonio and Borzatta Valerio, One-Pot Pictet-Spengler Reaction and Esterification for the Preparation of a Key Tadalafil Synthetic Intermediate, Letters in Organic Chemistry 2010; 7 (4) . https://dx.doi.org/10.2174/157017810791130667