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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Ceric Ammonium Nitrate: An Efficient Catalyst for One-Pot Synthesis of 2,2,4-Trimethyl-1,2-dihydroquinolines

Author(s): Shylaprasad Durgadas, Vijay K. Chatare, Khagga Mukkanti and Sarbani Pal

Volume 7, Issue 4, 2010

Page: [306 - 310] Pages: 5

DOI: 10.2174/157017810791130586

Price: $65

Abstract

Ceric ammonium nitrate (CAN) catalyzed the one-pot synthesis of 2,2,4-trimethyl-1,2-dihydroquinoline derivatives from substituted anilines and acetone via a modified Skraup reaction. The methodology was used to synthesize a novel dihydroquinoline-based compound derived from an anti-inflammatory agent nimesulide.

Keywords: CAN, catalysis, aniline, dihydroquinoline


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