Proteomic Identification of a Monoclonal Antibody Recognizing Caveolin-1 in Hepatocellular Carcinoma with Metastatic Potential

Title: Proteomic Identification of a Monoclonal Antibody Recognizing Caveolin-1 in Hepatocellular Carcinoma with Metastatic Potential

Volume: 16 Issue: 5

Author(s): Mei-yu Hu, Chi-tat Lam, Kang-da Liu, Zhi Xu, Sarwat Fatima, Yvonne C.F Su, Felice Tsang, Jie Chen, Jin-zhong Pang, Lun-xiu Qin and J. M. Luk

Affiliation:

Keywords: Hepatocellular carcinoma, caveolin-1, monoclonal antibody, metastasis

Abstract: A monoclonal antibody, McAb9E (IgG3), was generated against a metastatic HCC cell line, MHCC-1. The antigen was characterized as human Caveolin-1 (Cav-1, 21kDa), with pI of 5.65. The Cav-1 antigen was found significantly over expressed in metastatic HCC cell lines as well as in tumor specimens. The Cav-1 specific McAb may be a useful molecular agent for metastatic HCC.

Cite this article as:

Hu Mei-yu, Lam Chi-tat, Liu Kang-da, Xu Zhi, Fatima Sarwat, Su C.F Yvonne, Tsang Felice, Chen Jie, Pang Jin-zhong, Qin Lun-xiu and Luk M. J., Proteomic Identification of a Monoclonal Antibody Recognizing Caveolin-1 in Hepatocellular Carcinoma with Metastatic Potential, Protein & Peptide Letters 2009; 16 (5) . https://dx.doi.org/10.2174/092986609788167743