Second-Generation Histamine H2-Receptor Antagonists with Gastric Mucosal Defensive Properties

Title: Second-Generation Histamine H2-Receptor Antagonists with Gastric Mucosal Defensive Properties

Volume: 9 Issue: 5

Author(s): Takafumi Ichikawa, Kyoko Hotta and Kazuhiko Ishihara

Affiliation:

Keywords: Calcitonin gene-related peptide (CGRP), capsaicin-sensitive nerves, gastroprotective action, histamine HB2B-receptor antagonists, lafutidine, mucin, roxatidine, structure-activity relationship

Abstract: Unlike the earlier agents in this class, certain of the newer histamine HB2B-receptor antagonists (so-called secondgeneration HB2B-receptor antagonists) have recently been reported to promote gastric mucosal defenses. We review herein the structure, specificity, and mechanisms of these agents with a special focus on their cytoprotective/gastroprotective actions.

Cite this article as:

Ichikawa Takafumi, Hotta Kyoko and Ishihara Kazuhiko, Second-Generation Histamine H2-Receptor Antagonists with Gastric Mucosal Defensive Properties, Mini-Reviews in Medicinal Chemistry 2009; 9 (5) . https://dx.doi.org/10.2174/138955709788167646