Abstract
It has been proposed a novel method for obtaining of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid as Argmimetic within the framework of search for novel fibrinogen receptor antagonists. New αIIbβ3 antagonists were prepared on a base of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid. Their high antiaggregatory activities in a human platelet rich plasma and ability to block FITC-Fg binding to αIIbβ3 on washed human platelets were estimated.
Keywords: fibrinogen receptor antagonists, αIIbβ3, RGD mimetics, 1,2,3,4-tetrahydroisoquinoline, platelet aggregation
Medicinal Chemistry
Title: Derivatives of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic Acid as Novel Fibrinogen Receptor Antagonists
Volume: 5 Issue: 2
Author(s): Olga L. Malovichko, Andrei A. Krysko, Tatyana A. Kabanova, Sergei A. Andronati, Vladimir I. Grishkovets, Vadim V. Kachala and Denis A. Panov
Affiliation:
Keywords: fibrinogen receptor antagonists, αIIbβ3, RGD mimetics, 1,2,3,4-tetrahydroisoquinoline, platelet aggregation
Abstract: It has been proposed a novel method for obtaining of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid as Argmimetic within the framework of search for novel fibrinogen receptor antagonists. New αIIbβ3 antagonists were prepared on a base of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid. Their high antiaggregatory activities in a human platelet rich plasma and ability to block FITC-Fg binding to αIIbβ3 on washed human platelets were estimated.
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Cite this article as:
Malovichko L. Olga, Krysko A. Andrei, Kabanova A. Tatyana, Andronati A. Sergei, Grishkovets I. Vladimir, Kachala V. Vadim and Panov A. Denis, Derivatives of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic Acid as Novel Fibrinogen Receptor Antagonists, Medicinal Chemistry 2009; 5 (2) . https://dx.doi.org/10.2174/157340609787582909
DOI https://dx.doi.org/10.2174/157340609787582909 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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