Abstract
Aliphatic and aromatic nitriles are converted to corresponding amides in a single step via hydrolysis with basic H2O2 in aqueous solution of the surfactant Cetyltrimethylammonium methanesulfonate (CTAOMs). The method has several advantages: use and recycle of water as reaction medium, use of environmentally benign oxidant H2O2, easy product isolation, short reaction time, high yields and selectivity, mild conditions.
Keywords: Nitriles, hydrolysis, micelles, hydrogen peroxide, oxidation, amides
Letters in Organic Chemistry
Title: Efficient Hydrolysis of Nitriles to Amides with Hydroperoxide Anion in Aqueous Surfactant Solutions as Reaction Medium
Volume: 6 Issue: 2
Author(s): Lucia Brinchi, Lisa Chiavini, Laura Goracci, Pietro Di Profio and Raimondo Germani
Affiliation:
Keywords: Nitriles, hydrolysis, micelles, hydrogen peroxide, oxidation, amides
Abstract: Aliphatic and aromatic nitriles are converted to corresponding amides in a single step via hydrolysis with basic H2O2 in aqueous solution of the surfactant Cetyltrimethylammonium methanesulfonate (CTAOMs). The method has several advantages: use and recycle of water as reaction medium, use of environmentally benign oxidant H2O2, easy product isolation, short reaction time, high yields and selectivity, mild conditions.
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Cite this article as:
Brinchi Lucia, Chiavini Lisa, Goracci Laura, Di Profio Pietro and Germani Raimondo, Efficient Hydrolysis of Nitriles to Amides with Hydroperoxide Anion in Aqueous Surfactant Solutions as Reaction Medium, Letters in Organic Chemistry 2009; 6 (2) . https://dx.doi.org/10.2174/157017809787582708
DOI https://dx.doi.org/10.2174/157017809787582708 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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