Halogen Dance and Sequential Cross-Coupling on 2-Anilinothiazoles

Ather   Farooq   Khan; Michael      Schnurch; Marko   D.   Mihovilovic; Peter      Stanetty

doi:10.2174/157017809787582780

Abstract

A series of 4-bromo-5-halo and 4-bromo-5-organometal-2-anilinothiazole derivatives were prepared via the halogen dance (HD) reaction. Subsequent Pd-catalyzed Stille and Suzuki-Miyaura cross-coupling reactions were performed in a sequential manner to obtain novel 4,5-diarylated-2-anilinothiazoles.

Keywords: Pd-catalysis, cross-couplings, thiazole, halogen dance, sequential cross-couplings

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Letters in Organic Chemistry

Title: Halogen Dance and Sequential Cross-Coupling on 2-Anilinothiazoles

Volume: 6 Issue: 2

Author(s): Ather Farooq Khan, Michael Schnurch, Marko D. Mihovilovic and Peter Stanetty

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Keywords: Pd-catalysis, cross-couplings, thiazole, halogen dance, sequential cross-couplings

Abstract: A series of 4-bromo-5-halo and 4-bromo-5-organometal-2-anilinothiazole derivatives were prepared via the halogen dance (HD) reaction. Subsequent Pd-catalyzed Stille and Suzuki-Miyaura cross-coupling reactions were performed in a sequential manner to obtain novel 4,5-diarylated-2-anilinothiazoles.

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Khan Farooq Ather, Schnurch Michael, Mihovilovic D. Marko and Stanetty Peter, Halogen Dance and Sequential Cross-Coupling on 2-Anilinothiazoles, Letters in Organic Chemistry 2009; 6 (2) . https://dx.doi.org/10.2174/157017809787582780